Mesoscale trends look favorable for a couple of discrete supercells in far NE MO, initiating at around 22Z and tracking NE in an environment supporting top end SRH. The last two HRRR runs on simulated has a tornadic cell initiating around Edina, MO and moving towards Burlington, IL by 00Z. DPs already approaching 66F into central MO now. The current activity should be monitored for an OFB further enhancing the vectors.
The nocturnal risk into AR later is also looking serious and might well end up as the headline maker.